Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 6/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 6/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18266942 | 0.81 | CYP1A2 (0.57) | KDM4ELATS1LATS2KDM4C | |
| SCHEMBL29897413 | 0.81 | CDC7 (0.50) | CDC7KDM4EMAPKAPK2KDM5ALATS1 | |
| SCHEMBL3393299 | 0.81 | CDC7 (0.50) | CDC7KDM4EMAPKAPK2KDM5ALATS1 | |
| SCHEMBL16908309 | 0.79 | CDC7 (0.41) | CDC7KDM4EMAPKAPK2LATS1LATS2 | |
| SCHEMBL24174998 | 0.78 | NCF1 (0.59) | KDM4ELATS1LATS2 | |
| SCHEMBL19953773 | 0.78 | LMNA (0.53) | KDM4EL3MBTL1LATS1LATS2KDM4C | |
| SCHEMBL7261336 | 0.76 | MAOA (0.42) | KDM4EMAPKAPK2EP300KAT2BKAT8 | |
| SCHEMBL12653338 | 0.75 | TERT (0.50) | L3MBTL1LATS1LATS2 | |
| SCHEMBL21173380 | 0.75 | LATS1 (0.41) | LATS1LATS2KDM4C | |
| SCHEMBL30199873 | 0.75 | CYP1A2 (0.64) | KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144409-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6596730-B1 | Phenyl urea and phenyl thiourea derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-22 | — | — | US | disclosed |
| WO-2000047576-A1 | CINNAMIDE DERIVATIVES AS OREXIN-1 RECEPTORS ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |