Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.47 |
| ▸ | EDNRB | P24530 | 7/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634147 | 0.88 | DHODH (0.45) | EDNRBKDM4EALDH1A1KAT2BHPGD | |
| SCHEMBL7610547 | 0.84 | EDNRB (0.49) | EDNRBKDM4EPTGDR2HSD17B10 | |
| SCHEMBL6637441 | 0.81 | EDNRB (0.44) | EDNRBPTGDR2USP2KMT2AHSD17B10 | |
| SCHEMBL6634786 | 0.81 | PRKCB (0.44) | EDNRBFEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL7849658 | 0.77 | TACR1 (0.54) | KDM4EALDH1A1KAT2BUSP2HPGD | |
| SCHEMBL11078500 | 0.76 | FEN1 (0.52) | FEN1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL6636706 | 0.75 | WEE1 (0.44) | PADI4FEN1KDM4EALDH1A1PTGDR2 | |
| SCHEMBL11080007 | 0.75 | FEN1 (0.51) | PADI4FEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL6637488 | 0.75 | ACAT1 (0.49) | — | |
| SCHEMBL6633528 | 0.74 | DHODH (0.46) | EDNRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842933-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-08-04 | — | — | EP | disclosed |
| US-5843957-A | Naphthyridine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0842933-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |