Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636706 | 0.85 | WEE1 (0.44) | KMT2AKDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL11076507 | 0.83 | L3MBTL1 (0.53) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8137427 | 0.80 | ALDH1A1 (0.65) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL11169434 | 0.79 | KDM4E (0.51) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8786825 | 0.79 | MEN1 (0.54) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL8784656 | 0.78 | ALDH1A1 (0.54) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL6638162 | 0.78 | ALOX5 (0.51) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9359243 | 0.77 | ALDH1A1 (0.53) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL9042136 | 0.76 | MEN1 (0.46) | MEN1KMT2APOLBPABPC1KDM4E | |
| SCHEMBL9358921 | 0.75 | POLB (0.53) | MEN1KMT2APOLBPABPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842933-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-08-04 | — | — | EP | disclosed |
| EP-0947515-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-10-06 | — | — | EP | disclosed |
| US-5843957-A | Naphthyridine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0842933-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |