Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358730 | 0.80 | LMNA (0.44) | WEE1KMT2AMEN1MAP3K5NPC1 | |
| SCHEMBL8544707 | 0.80 | KMT2A (0.47) | WEE1KMT2ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL6636706 | 0.79 | WEE1 (0.44) | WEE1KMT2APADI4RAB9ANPC1 | |
| SCHEMBL9358757 | 0.76 | EDNRB (0.42) | WEE1KMT2ARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9358984 | 0.76 | KDM4E (0.41) | WEE1KMT2AMEN1MAP3K5NPC1 | |
| SCHEMBL6634344 | 0.75 | ROCK2 (0.41) | ROCK2WEE1 | |
| SCHEMBL27396929 | 0.75 | EGFR (0.54) | KMT2APADI4RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9358837 | 0.73 | KMT2A (0.40) | WEE1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9358745 | 0.71 | TACR1 (0.43) | KMT2AMEN1MAP3K5POLBL3MBTL1 | |
| SCHEMBL9363440 | 0.69 | KMT2A (0.46) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842933-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-08-04 | — | — | EP | disclosed |
| CN-1065243-C | Naphthyridine derivs. | SUMITOMO PHARMA (JP) | 2001-05-02 | — | — | CN | disclosed |
| EP-0947515-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-10-06 | — | — | EP | disclosed |
| US-5843957-A | Naphthyridine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1998-12-01 | — | — | US | disclosed |
| CN-1191536-A | Naphthyridine derivs. | SUMITOMO PHARMA (JP) | 1998-08-26 | — | — | CN | disclosed |
| EP-0842933-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |