Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9363440 | 0.89 | KMT2A (0.46) | KMT2AEGFRMEN1KDM4EIKBKB | |
| SCHEMBL27337810 | 0.88 | KMT2A (0.46) | KMT2AEGFRMEN1KDM4EIKBKB | |
| SCHEMBL9358757 | 0.86 | EDNRB (0.42) | KMT2AMEN1KDM4ECHEK1WEE1 | |
| SCHEMBL9358984 | 0.86 | KDM4E (0.41) | KMT2AMEN1KDM4ECHEK1WEE1 | |
| SCHEMBL8784716 | 0.86 | IKBKB (0.55) | KMT2AEGFRIKBKBCHUKAKT1 | |
| SCHEMBL9358730 | 0.85 | LMNA (0.44) | KMT2AMEN1WEE1NPC1 | |
| SCHEMBL8784656 | 0.84 | ALDH1A1 (0.54) | KMT2AMEN1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8543014 | 0.81 | KDM4E (0.44) | KMT2AEGFRMEN1KDM4ECHEK1 | |
| SCHEMBL6636719 | 0.80 | ROCK2 (0.43) | KMT2AMEN1WEE1SMN1; SMN2NPC1 | |
| SCHEMBL27396929 | 0.78 | EGFR (0.54) | KMT2AEGFRMEN1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623112-B1 | 4-Phenyl-3-(heteroarylureido)-1,2-dihydro-2-oxoquinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | PFIZER (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5565472-A | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | PFIZER INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0421456-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| EP-0623112-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993015058-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |
| US-5223513-A | Anticholesterol agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0421456-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |