Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640173 | 0.85 | CTSB (0.54) | CTSBMAPTHPGDNPC1RAB9A | |
| SCHEMBL8135600 | 0.83 | CTSB (0.55) | CTSBMAPTHPGDNPC1RAB9A | |
| SCHEMBL13067221 | 0.80 | MAPT (0.44) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1520770 | 0.80 | RAB9A (0.78) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6639098 | 0.79 | RAB9A (0.56) | HPGDNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL6641196 | 0.79 | RAB9A (0.56) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL6354561 | 0.79 | MEN1 (0.56) | CTSBMAPTHPGDNPC1RAB9A | |
| SCHEMBL6640347 | 0.79 | RAB9A (0.56) | HPGDNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL6639637 | 0.79 | RAB9A (0.81) | CTSBMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6643095 | 0.79 | RAB9A (0.53) | CTSBMAPTHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449835-A2 | Alpha-substituted pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1247804-A1 | Pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |