Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22446381 | 0.81 | PRMT5 (0.47) | PRMT5TLR8TLR7PDPK1LMNA | |
| SCHEMBL9710251 | 0.80 | PRMT5 (0.46) | PRMT5TLR8TLR7LMNATOP1 | |
| SCHEMBL6637754 | 0.77 | PRMT5 (0.59) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL23676516 | 0.77 | PRMT5 (0.68) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL21940318 | 0.75 | KDM4E (0.50) | PRMT5LMNA | |
| SCHEMBL9709703 | 0.74 | NCF1 (0.59) | TLR8TLR7LMNA | |
| SCHEMBL28332633 | 0.74 | PRMT5 (0.50) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL21849073 | 0.71 | LMNA (0.43) | PRMT5LMNANSD2CASP6G6PD | |
| SCHEMBL11373687 | 0.70 | SYK (0.50) | TLR8TLR7PDPK1MAP4K4LMNA | |
| SCHEMBL8351207 | 0.69 | PDE10A (0.48) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |