Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | TOP1 | P11387 | 6/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23676516 | 0.81 | PRMT5 (0.68) | PRMT5TOP1HSP90AA1HSP90AB1CASP6 | |
| SCHEMBL30625771 | 0.78 | MMP2 (0.46) | PRMT5TOP1HSP90AA1CASP6KDM4E | |
| SCHEMBL6637754 | 0.78 | PRMT5 (0.59) | PRMT5TOP1CASP6KDM4EALDH1A1 | |
| SCHEMBL9709781 | 0.74 | PRMT5 (0.54) | PRMT5TOP1CASP6LMNAHRH4 | |
| SCHEMBL2471617 | 0.73 | SLC40A1 (0.47) | PRMT5HSP90AA1HSP90AB1CASP6KDM4E | |
| SCHEMBL5822770 | 0.71 | PDE10A (0.45) | PRMT5TOP1HSP90AA1HSP90AB1CASP6 | |
| SCHEMBL27293402 | 0.71 | NCF1 (0.60) | KDM4ETP53MAPTTSHRHTT | |
| SCHEMBL544243 | 0.70 | NCF1 (0.54) | PRMT5HSP90AA1HSP90AB1CASP6KDM4E | |
| Hydrochloric Acid SCHEMBL26697692 | 0.68 | NCF1 (0.52) | PRMT5HSP90AA1HSP90AB1CASP6KDM4E | |
| SCHEMBL29517215 | 0.67 | DHFR (0.54) | PRMT5HSP90AA1KDM4ETP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110386945-A | A kind of big ring class kinase inhibitor | 成都先导药物开发股份有限公司 | 2019-10-29 | — | — | CN | disclosed |