Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 20/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 17/20 | 0.55 |
| ▸ | F2 | P00734 | 5/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638363 | 1.00 | F10 (0.55) | F10PRSS1F2PLGTMPRSS2 | |
| SCHEMBL12521570 | 0.85 | F10 (0.71) | F10PRSS1F2PLGTMPRSS2 | |
| SCHEMBL6639294 | 0.82 | F10 (0.55) | F10PRSS1F2PLGTMPRSS2 | |
| SCHEMBL6639291 | 0.82 | F10 (0.55) | F10PRSS1F2PLGTMPRSS2 | |
| Trifluoroacetic Acid SCHEMBL6641247 | 0.80 | F10 (0.73) | F10PRSS1F2PLGTMPRSS2 | |
| Trifluoroacetic Acid SCHEMBL7902234 | 0.80 | F10 (0.73) | F10PRSS1F2PLGTMPRSS2 | |
| SCHEMBL13636689 | 0.74 | NLRP3 (0.48) | F10PRSS1F2PLGTMPRSS2 | |
| SCHEMBL15607589 | 0.74 | NLRP3 (0.51) | — | |
| SCHEMBL4955572 | 0.74 | DPP4 (0.42) | — | |
| SCHEMBL7898536 | 0.74 | F10 (0.57) | F10PRSS1F2PLGTMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931060-A4 | SUBSTITUTED N- (AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES | AVENTIS PHARMA INC (US) | 2004-10-06 | — | — | EP | disclosed |
| US-6323227-B1 | PRODRUGS | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-11-27 | — | — | US | disclosed |
| EP-0931060-A1 | SUBSTITUTED N- (AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1999000356-A1 | SUBSTITUTED N-[(AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES | RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) | 1999-01-07 | — | — | WO | disclosed |