Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 9/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1E | P28566 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR5A | P47898 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18706270 | 0.84 | SLC6A4 (0.40) | HTR2AHTR2CCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7400862 | 0.80 | DRD2 (0.35) | HTR6 | |
| SCHEMBL10748671 | 0.79 | TAAR1 (0.49) | HTR2AHTR6HTR2CHTR1AHTR1D | |
| SCHEMBL7386695 | 0.79 | CYP2D6 (0.41) | CYP1A2CYP2D6SLC6A2 | |
| SCHEMBL8917172 | 0.79 | TAAR1 (0.36) | CYP1A2AOC3 | |
| SCHEMBL9053089 | 0.77 | HRH2 (0.37) | HTR2ACYP1A2CYP2D6CYP2C9L3MBTL1 | |
| SCHEMBL8183757 | 0.77 | ALDH1A1 (0.36) | HTR2ACYP1A2CYP2D6CYP2C9AOC3 | |
| SCHEMBL462206 | 0.76 | PTGS2 (0.42) | HTR2AL3MBTL1 | |
| SCHEMBL457740 | 0.76 | CA1 (0.35) | CYP1A2 | |
| SCHEMBL10612033 | 0.75 | HTR2A (0.41) | HTR2AHTR6HTR2CHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |