Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22093267 | 0.85 | MAT2A (0.46) | MAT2AGAAALDH1A1KDM4EHCAR1 | |
| SCHEMBL31145405 | 0.85 | MAT2A (0.46) | MAT2AGAAALDH1A1KDM4EHCAR1 | |
| SCHEMBL31145399 | 0.82 | MAT2A (0.57) | MAT2AGAAPARP1ALDH1A1KDM4E | |
| SCHEMBL22093132 | 0.82 | MAT2A (0.57) | MAT2AGAAPARP1ALDH1A1KDM4E | |
| SCHEMBL22093370 | 0.79 | MAT2A (0.46) | MAT2AALDH1A1MEN1KMT2A | |
| SCHEMBL22094368 | 0.79 | MAT2A (0.46) | MAT2AGAAALDH1A1KDM4EHCAR1 | |
| SCHEMBL31145263 | 0.79 | MAT2A (0.49) | MAT2AGAAALDH1A1KDM4EDHFR | |
| SCHEMBL22094011 | 0.79 | MAT2A (0.47) | MAT2AALDH1A1KDM4EDHFRHPGD | |
| SCHEMBL22093125 | 0.79 | MAT2A (0.49) | MAT2AGAAALDH1A1KDM4EDHFR | |
| SCHEMBL31145271 | 0.79 | MAT2A (0.47) | MAT2AALDH1A1KDM4EDHFRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994113-B1 | 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | claimed |
| US-6242452-B1 | EXHIBIT EXCELLENT BRONCHODILATING ACTION WITH LOW SIDE EFFECTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | claimed |
| EP-0994113-A2 | 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | claimed |
| CN-1193029-C | New 7-amino pyrido[2,3-d] pyrimidine derivative | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2005-03-16 | — | — | CN | disclosed |
| EP-0994113-B1 | 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| EP-1145716-B1 | Therapeutic agent for the treatment of dermatitis | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2004-08-04 | — | — | EP | disclosed |
| US-6440978-B2 | A THERAPEUTICAL AGENT FOR DERMATITIS COMPRISES 7-AMINO-3-(HALO SUBSTITUTED OR UNSUBSTITUED BENZYL)-1,2,3-TETRAHYDRO-1-PHENYLPYRIDO(2,3-D)PYRIMIDIN-2,4-DIONE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2002-08-27 | — | — | US | disclosed |
| US-20010056097-A1 | Therapeutic agent for dermatitis | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2001-12-27 | — | — | US | disclosed |
| EP-1145716-A2 | Therapeutic agent for the treatment of dermatitis | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-6242452-B1 | EXHIBIT EXCELLENT BRONCHODILATING ACTION WITH LOW SIDE EFFECTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| US-6242452-B1 | EXHIBIT EXCELLENT BRONCHODILATING ACTION WITH LOW SIDE EFFECTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| CN-1293194-A | New 7-amino pyrido[2,3-d] pyrimidine derivative | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2001-05-02 | — | — | CN | disclosed |
| EP-0994113-A3 | 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2000-05-24 | — | — | EP | disclosed |
| JP-2000119272-A | NEW 7-AMINOPYRIDO[2,3-D]PYRIMIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUT CO LTD | 2000-04-25 | — | — | JP | disclosed |
| EP-0994113-A2 | 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |
| EP-0994113-A2 | 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056097-A1 | Therapeutic agent for dermatitis | CCL11, TSLP, HRH4 | MAT2A 4494/4885GAA 4606/4885PARP1 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.