Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | QPCT | Q16769 | 1/20 | 0.48 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435590 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL6641997 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL6844539 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL6641388 | 0.81 | HRH3 (0.50) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL6638755 | 0.81 | HRH3 (0.61) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL11285011 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL19220371 | 0.77 | HPGD (0.42) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL6637278 | 0.76 | HRH3 (0.62) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL6636102 | 0.74 | HRH3 (1.00) | HRH3 | |
| SCHEMBL11079317 | 0.73 | ALDH1A1 (0.67) | KDM4EALDH1A1GAAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562913-B2 | Indolizine-based dyes for dye-sensitized solar cell | UNIVERSITY OF MISSISSIPPI (US) | 2020-02-18 | — | — | US | disclosed |
| US-20170226125-A1 | INDOLIZINE-BASED DYES FOR DYE-SENSITIZED SOLAR CELL | UNIVERSITY OF MISSISSIPPI | 2017-08-10 | — | — | US | disclosed |
| US-20170226125-A1 | INDOLIZINE-BASED DYES FOR DYE-SENSITIZED SOLAR CELL | UNIVERSITY OF MISSISSIPPI | 2017-08-10 | — | — | US | disclosed |
| EP-1268479-B1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | ORTHO MCNEIL PHARM INC (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1268479-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20010051632-A1 | Phenyl-substituted indolizines and tetrahydroindolizines | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2001-12-13 | — | — | US | disclosed |
| WO-2001074814-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226125-A1 | INDOLIZINE-BASED DYES FOR DYE-SENSITIZED SOLAR CELL | INMT, IDO1, IDO2 | KDM4E 1805/4885ALDH1A1 1602/4885GAA 3253/4885 |
| US-20010051632-A1 | Phenyl-substituted indolizines and tetrahydroindolizines | TPH2, TPH1, IDO2 | KDM4E 1223/4885ALDH1A1 967/4885GAA 2400/4885 |
| US-10562913-B2 | Indolizine-based dyes for dye-sensitized solar cell | INMT, IDO1, IDO2 | KDM4E 1805/4885ALDH1A1 1602/4885GAA 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.