Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DUT | P33316 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356225 | 0.91 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL30840869 | 0.83 | DUT (0.38) | ALDH1A1DUTPPARGPPARAIDO1 | |
| SCHEMBL17100452 | 0.82 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| Acetaldehyde SCHEMBL8696394 | 0.82 | IDO1 (0.46) | LMNADUTIDO1KMT2A | |
| SCHEMBL979052 | 0.81 | BACE1 (0.40) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL14183641 | 0.81 | KCNH2 (0.42) | LMNADUTCYP2A6IDO1 | |
| SCHEMBL410888 | 0.80 | DUT (0.40) | ALDH1A1SMN1; SMN2DUTPPARAIDO1 | |
| SCHEMBL662532 | 0.80 | DUT (0.40) | ALDH1A1LMNASMN1; SMN2DUTPPARG | |
| SCHEMBL14832628 | 0.80 | MAOB (0.43) | ALDH1A1MAPTDUTIDO1KMT2A | |
| SCHEMBL30859481 | 0.80 | DUT (0.40) | ALDH1A1DUTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ALDH1A1 2104/4885LMNA 1559/4885MAPT 3436/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | ALDH1A1 2078/4885LMNA 1587/4885MAPT 3785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.