Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 17/20 | 0.71 |
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.71 |
| ▸ | TP53 | P04637 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | HTT | P42858 | 5/20 | 0.70 |
| ▸ | NPY1R | P25929 | 1/20 | 0.64 |
| ▸ | NPY2R | P49146 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 5/20 | 0.55 |
| ▸ | PKLR | P30613 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966999 | 0.82 | GAA (1.00) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL20889799 | 0.79 | GAA (0.67) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL20889727 | 0.78 | GAA (0.77) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL20889290 | 0.78 | GAA (0.65) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL20889563 | 0.75 | GAA (0.76) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL14421383 | 0.75 | PKM (0.79) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL1966995 | 0.75 | ADORA1 (0.63) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL2611912 | 0.75 | GAA (0.61) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL20889704 | 0.74 | GAA (0.66) | GAAMAPTSMN1; SMN2HPGDTP53 | |
| SCHEMBL20889798 | 0.74 | NR1H4 (0.71) | GAAMAPTSMN1; SMN2HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218382-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6638933-B2 | Analgesics | GRUENENTHAL GMBH (DE) | 2003-10-28 | — | — | US | claimed |
| JP-2003511451-A | — | — | 2003-03-25 | — | — | JP | claimed |
| EP-1218382-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001027111-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |
| EP-1218382-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | GRUENENTHAL GMBH | 2003-01-23 | — | — | US | disclosed |
| EP-1218382-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027111-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | OPRK1, IPO4, GRIN3A | GAA 3278/4885MAPT 1832/4885SMN1; SMN2 2223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.