SCHEMBL6645873

SCHEMBL6645873

O=C1C[N+](=O)Cc2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.47
MAOB P27338 2/20 0.47
CYP2A6 P11509 1/20 0.47
CES1 P23141 2/20 0.43
BCHE P06276 1/20 0.43
ACHE P22303 2/20 0.38
KMT2A Q03164 2/20 0.38
CA12 O43570 1/20 0.38
CA9 Q16790 1/20 0.38
ALDH1A1 P00352 3/20 0.37
KDM4E B2RXH2 2/20 0.37
HPGD P15428 2/20 0.37
CYP19A1 P11511 1/20 0.36
CYP1A2 P05177 2/20 0.36
PDPK1 O15530 1/20 0.35
PARP1 P09874 1/20 0.35
PARP10 Q53GL7 1/20 0.35
PARP11 Q9NR21 1/20 0.35
TDP2 O95551 1/20 0.35
CASP3 P42574 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2474526 0.78 CYP1A2 (0.41) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL1538761 0.71 MAOA (0.43) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL31070117 0.69
SCHEMBL8035811 0.69 CES1 (0.73) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL569873 0.69
SCHEMBL1553785 0.68 MAOB (0.42) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL24746 0.67 MAOA (0.74) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL1268680 0.67 MAOA (0.74) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL29353311 0.67 MAOA (0.74) MAOAMAOBCYP2A6CES1BCHE
SCHEMBL7731659 0.67 CA12 (0.48) MAOAMAOBCYP2A6CES1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2619203-A1 TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES Glaxo Group Limited (GB) 2013-07-31 EP disclosed
WO-2012037782-A1 TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES GLAXO GROUP LIMITED (GB) 2012-03-29 WO disclosed
EP-1417196-A1 DNA-PK INHIBITORS Cancer Research Technology Limited (GB) 2004-05-12 EP disclosed
WO-2003024949-A1 DNA-PK INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2003-03-27 WO disclosed