SCHEMBL6645882

SCHEMBL6645882

COC(=O)c1ccc(Cl)cc1OS(=O)(=O)C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.50
FLT1 P17948 2/20 0.44
FLT4 P35916 2/20 0.44
KDR P35968 2/20 0.44
EPAS1 Q99814 1/20 0.44
NR4A2 P43354 2/20 0.42
ALPL P05186 1/20 0.42
PDK2 Q15119 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CFTR P13569 1/20 0.40
AVPR2 P30518 2/20 0.40
GPR27 Q9NS67 2/20 0.40
POLB P06746 1/20 0.40
MCOLN3 Q8TDD5 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CNR2 P34972 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15826901 0.89 EPAS1 (0.49) ABL1EPAS1NR4A2ALPLPDK2
SCHEMBL17913590 0.86 EPAS1 (0.45) ABL1FLT1FLT4KDREPAS1
SCHEMBL3494530 0.86 HSD11B1 (0.45) ABL1FLT1FLT4KDREPAS1
SCHEMBL974920 0.86 HSD11B1 (0.45) EPAS1PDK2SLC6A3CFTRL3MBTL1
SCHEMBL26619763 0.84 CA12 (0.51) EPAS1PDK2SLC6A3CFTRL3MBTL1
SCHEMBL6643810 0.84 HSP90AA1 (0.43) EPAS1NR4A2PDK2SLC6A3CFTR
SCHEMBL4634289 0.84 FFAR4 (0.52) EPAS1PDK2SLC6A4SLC6A3CFTR
SCHEMBL294877 0.83 KDM4E (0.44) NR4A2CFTRMEN1KMT2AGAA
SCHEMBL16593084 0.83 L3MBTL1 (0.42) EPAS1NR4A2ALPLPDK2SLC6A3
SCHEMBL16750947 0.83 CFTR (0.57) CFTRAVPR2GPR27L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015041428-A1 ORGANIC ELECTRONIC ELEMENT USING COMPOUND FOR ORGANIC ELECTRONIC ELEMENT AND ELECTRONIC DEVICE THEREOF 덕산네오룩스 주식회사 2015-03-26 WO disclosed
US-20040133008-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-07-08 US disclosed
US-20040106653-A1 Aminoalcohol derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-06-03 US disclosed
WO-2004045610-A1 AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD (JP) 2004-06-03 WO disclosed
WO-2004039795-A2 AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-05-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040133008-A1 Amide compounds APOB, APOL1, LDLR ABL1 721/4885FLT1 2160/4885FLT4 3564/4885
US-20040106653-A1 Aminoalcohol derivatives FANCD2, FANCI, HRH2 ABL1 3903/4885FLT1 4699/4885FLT4 4804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.