Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | BCL3 | P20749 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776235 | 1.00 | HCRTR1 (0.48) | HCRTR1HCRTR2ALDH1A1DPP4BCL3 | |
| SCHEMBL1779310 | 0.91 | HPGD (0.45) | HCRTR1HCRTR2ALDH1A1DPP4MAPT | |
| SCHEMBL6641310 | 0.87 | ALDH1A1 (0.42) | HCRTR1HCRTR2ALDH1A1DPP4L3MBTL1 | |
| SCHEMBL1777384 | 0.87 | ALDH1A1 (0.42) | HCRTR1HCRTR2ALDH1A1DPP4L3MBTL1 | |
| SCHEMBL6646483 | 0.79 | RHOC (0.39) | HCRTR1HCRTR2ALDH1A1DPP4NPC1 | |
| SCHEMBL1778081 | 0.79 | RHOC (0.39) | HCRTR1HCRTR2ALDH1A1DPP4NPC1 | |
| SCHEMBL1777409 | 0.79 | HCRTR1 (0.49) | HCRTR1HCRTR2MAPTL3MBTL1 | |
| SCHEMBL1779433 | 0.77 | L3MBTL1 (0.54) | HCRTR1HCRTR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL1779434 | 0.77 | L3MBTL1 (0.54) | HCRTR1HCRTR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL1777690 | 0.75 | RAB9A (0.51) | ALDH1A1NPC1KMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406897-A2 | COMPOUNDS | SmithKline Beecham plc (GB) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003002559-A2 | PIPERIDINE COMPOUNDS FOR USE AS OREXIN RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-01-09 | — | — | WO | disclosed |