Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644469 | 0.92 | HTR2C (0.38) | HTR2CENPP2ALDH1A1LMNAPANK3 | |
| SCHEMBL7123729 | 0.89 | ENPP2 (0.39) | HTR2CENPP2ALDH1A1LMNAPANK3 | |
| SCHEMBL6011781 | 0.88 | GPR119 (0.44) | ENPP2GPR119NR1H2NR1H3CNR1 | |
| SCHEMBL6648472 | 0.87 | HTR2C (0.37) | HTR2CENPP2ALDH1A1LMNAPANK3 | |
| SCHEMBL5077591 | 0.83 | ALDH1A1 (0.41) | HTR2CENPP2ALDH1A1LMNACNR1 | |
| SCHEMBL6011689 | 0.83 | KMT2A (0.44) | ENPP2ALDH1A1LMNA | |
| SCHEMBL5075675 | 0.83 | ENPP2 (0.43) | HTR2CENPP2ALDH1A1LMNAPANK3 | |
| SCHEMBL5082046 | 0.83 | CYP3A4 (0.45) | HTR2CENPP2ALDH1A1LMNAPANK3 | |
| SCHEMBL6011570 | 0.82 | TP53 (0.42) | ENPP2ALDH1A1LMNA | |
| SCHEMBL6011375 | 0.82 | SMN1; SMN2 (0.43) | HTR2CENPP2ALDH1A1PANK3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |