Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 7/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628971 | 0.89 | KDM4E (0.51) | SREBF2CYP19A1CDK5CDK5R1L3MBTL1 | |
| SCHEMBL6648508 | 0.84 | KDM4E (0.51) | SREBF2CYP19A1L3MBTL1KDM4EKMT2A | |
| SCHEMBL6650983 | 0.83 | CYP19A1 (0.49) | CYP19A1CDK5CDK5R1L3MBTL1KDM4E | |
| SCHEMBL6626251 | 0.81 | KDM4E (0.52) | CYP19A1CDK5CDK5R1L3MBTL1KDM4E | |
| SCHEMBL6649838 | 0.81 | KDM4E (0.59) | SREBF2CYP19A1L3MBTL1KDM4EMAPT | |
| SCHEMBL6646344 | 0.80 | KDM4E (0.57) | SREBF2CYP19A1KDM4EMEN1KMT2A | |
| SCHEMBL6647943 | 0.80 | KDM4E (0.43) | CYP19A1CDK5CDK5R1L3MBTL1KDM4E | |
| SCHEMBL6649845 | 0.80 | RAB9A (0.59) | SREBF2CYP19A1L3MBTL1KDM4EMAPT | |
| SCHEMBL6649722 | 0.80 | SREBF2 (0.46) | SREBF2CYP19A1KDM4EMEN1KMT2A | |
| SCHEMBL6648190 | 0.79 | KDM4E (0.52) | SREBF2CYP19A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |