Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 12/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046264 | 0.85 | HTR2A (0.48) | KCNH2CYP2D6 | |
| SCHEMBL6659265 | 0.81 | POLB (0.44) | LTA4HEPHX2CYP2D6HRH1 | |
| SCHEMBL6617305 | 0.80 | CHRNB4 (0.47) | — | |
| SCHEMBL6619348 | 0.78 | CHRNB4 (0.47) | CCR3CYP2D6 | |
| SCHEMBL6647024 | 0.78 | SSTR5 (0.47) | KCNH2 | |
| SCHEMBL6617259 | 0.77 | CHRNB4 (0.42) | CCR3CYP2D6 | |
| SCHEMBL6618399 | 0.76 | MEN1 (0.48) | KCNH2CCR3 | |
| SCHEMBL6614953 | 0.76 | KDM4E (0.40) | CCR3 | |
| SCHEMBL6614327 | 0.75 | CYP3A4 (0.48) | CCR3CYP2D6 | |
| SCHEMBL6618307 | 0.75 | CACNA1B (0.44) | LTA4HEPHX2CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003018566-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-06 | — | — | WO | disclosed |