Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617259 | 0.88 | CHRNB4 (0.42) | CHRNB4CHRNA3CHRNB2CHRNA4CCR3 | |
| SCHEMBL6617305 | 0.85 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL4051310 | 0.83 | ALDH1A1 (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4MAPT | |
| SCHEMBL6618307 | 0.82 | CACNA1B (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4CCR3 | |
| SCHEMBL6618399 | 0.81 | MEN1 (0.48) | MAPTCCR3ALDH1A1POLB | |
| SCHEMBL6647024 | 0.81 | SSTR5 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4MAPT | |
| SCHEMBL6659265 | 0.81 | POLB (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL6614953 | 0.81 | KDM4E (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4CCR3 | |
| SCHEMBL6614327 | 0.79 | CYP3A4 (0.48) | CCR3CYP2D6ALDH1A1 | |
| SCHEMBL6614746 | 0.79 | HRH3 (0.46) | CHRNB4CHRNA3CCR3CYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | claimed |
| WO-2003018566-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-06 | — | — | WO | claimed |
| EP-1421070-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003018566-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-06 | — | — | WO | disclosed |