Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224500 | 0.84 | DRD2 (0.48) | LMNACYP2C19CYP2D6HRH1 | |
| SCHEMBL6617305 | 0.83 | CHRNB4 (0.47) | POLBSLC6A2SLC6A4SLC6A3CHRNB4 | |
| SCHEMBL6619348 | 0.81 | CHRNB4 (0.47) | POLBCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6648474 | 0.81 | PTGS1 (0.46) | CYP2D6HRH1LTA4HEPHX2 | |
| SCHEMBL6617259 | 0.79 | CHRNB4 (0.42) | POLBSLC6A2SLC6A4SLC6A3CHRNB4 | |
| SCHEMBL6647024 | 0.77 | SSTR5 (0.47) | POLBLMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6614953 | 0.77 | KDM4E (0.40) | POLBSLC6A2SLC6A4SLC6A3CHRNB4 | |
| SCHEMBL6614327 | 0.77 | CYP3A4 (0.48) | CYP2C19CYP2D6 | |
| SCHEMBL6614746 | 0.77 | HRH3 (0.46) | CHRNB4CHRNA3CYP2D6 | |
| SCHEMBL6618307 | 0.77 | CACNA1B (0.44) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003018566-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-06 | — | — | WO | disclosed |