Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 4/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054869 | 0.85 | DRD2 (0.48) | CACNA1BCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6617305 | 0.82 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL6619348 | 0.82 | CHRNB4 (0.47) | CHRNB4CHRNA3CCR3CHRNB2CHRNA4 | |
| SCHEMBL6617259 | 0.81 | CHRNB4 (0.42) | CHRNB4CHRNA3CCR3CHRNB2CHRNA4 | |
| SCHEMBL6647024 | 0.78 | SSTR5 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL6614953 | 0.78 | KDM4E (0.40) | CHRNB4CHRNA3CCR3CHRNB2CHRNA4 | |
| SCHEMBL6614746 | 0.78 | HRH3 (0.46) | CHRNB4CHRNA3CCR3MAOB | |
| SCHEMBL6618399 | 0.77 | MEN1 (0.48) | CCR3MAOB | |
| SCHEMBL6659265 | 0.77 | POLB (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL6614327 | 0.76 | CYP3A4 (0.48) | CCR3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003018566-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-06 | — | — | WO | disclosed |