Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 1/20 | 0.55 |
| ▸ | EIF4E | P06730 | 10/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651418 | 0.87 | C1S (0.54) | C1SEIF4EMAPTMEN1KMT2A | |
| SCHEMBL6648675 | 0.86 | EIF4E (0.58) | EIF4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6651612 | 0.84 | C1S (0.54) | C1SEIF4EMAPTMEN1KMT2A | |
| SCHEMBL6648546 | 0.81 | MAOA (0.52) | EIF4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6651017 | 0.80 | C1S (0.47) | C1SEIF4EMAPTMEN1KMT2A | |
| SCHEMBL6646406 | 0.80 | KDM4E (0.61) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL6646768 | 0.78 | CYP19A1 (0.56) | EIF4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6646510 | 0.77 | CDC25A (0.56) | C1SMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6649219 | 0.77 | EIF4E (0.44) | EIF4ENPC1 | |
| SCHEMBL6628863 | 0.76 | CYP19A1 (0.48) | MEN1KMT2AALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |