Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10154090 | 0.90 | KCNA5 (0.47) | KCNA5LMNAALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL9953409 | 0.90 | POLB (0.50) | KCNA5POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10153615 | 0.87 | SCN9A (0.54) | KCNA5LMNAPOLBALDH1A1HPGD | |
| SCHEMBL11800163 | 0.86 | KCNA5 (0.55) | KCNA5LMNAPOLBALDH1A1MC4R | |
| SCHEMBL9958520 | 0.86 | ERCC1 (0.47) | KCNA5 | |
| SCHEMBL9958635 | 0.83 | ALDH1A1 (0.50) | LMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9959313 | 0.82 | KCNA5 (0.48) | KCNA5LMNAPOLBUSP2ALDH1A1 | |
| SCHEMBL10153587 | 0.82 | MAPT (0.59) | LMNAPOLBUSP2ALDH1A1HPGD | |
| SCHEMBL10153604 | 0.82 | KCNA5 (0.47) | KCNA5LMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL6649484 | 0.81 | LMNA (0.69) | KCNA5LMNAUSP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | claimed |
| US-20190070165-A1 | N-HYDROXYISOQUINOLINEDIONE INHIBITORS OF HBV REPLICATION | SAINT LOUIS UNIVERSITY (US) | 2019-03-07 | — | — | US | disclosed |
| WO-2017161133-A1 | N-HYDROXYISOQUINOLINEDIONE INHIBITORS OF HBV REPLICATION | SAINT LOUIS UNIVERSITY (US) | 2017-09-21 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070165-A1 | N-HYDROXYISOQUINOLINEDIONE INHIBITORS OF HBV REPLICATION | HCCS, HAVCR2, HDGF | KCNA5 4831/4885LMNA 1966/4885POLB 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.