Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | C1R | P00736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3154185 | 0.84 | ELANE (0.33) | CYP1A2ALDH1A1ELANENPSR1CA1 | |
| SCHEMBL4453364 | 0.83 | ADORA3 (0.36) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6237071 | 0.83 | DHFR (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5926708 | 0.79 | CES1 (0.37) | NPC1RAB9ASMN1; SMN2CYP1A2ALDH1A1 | |
| SCHEMBL6234916 | 0.76 | HDAC4 (0.43) | SMN1; SMN2NOTUMCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL7008716 | 0.76 | — | — | |
| SCHEMBL6443094 | 0.74 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL3147081 | 0.73 | BRD4 (0.30) | BRD4 | |
| SCHEMBL6234188 | 0.71 | ELANE (0.37) | ELANE | |
| SCHEMBL6723398 | 0.71 | CA2 (0.35) | ALDH1A1TSHRELANECA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444195-A2 | PROCESS FOR THE PREPARATION OF ALPHA-HYDROXYCARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003042166-A2 | PROCESS FOR PREPARATION OF α-HYDROXYCARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-05-22 | — | — | WO | disclosed |