Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780409 | 0.84 | HTR6 (0.66) | HTR6ALDH1A1GAAPKMALOX15 | |
| SCHEMBL3353772 | 0.74 | HTR6 (0.62) | HTR6ALDH1A1PNMTHTR2CHTR2B | |
| SCHEMBL7452220 | 0.72 | HTR6 (0.84) | HTR6ALDH1A1PNMTHTR2CHTR2B | |
| SCHEMBL10357482 | 0.72 | HTR6 (0.84) | HTR6ALDH1A1PKMPNMTHTR2C | |
| SCHEMBL5778392 | 0.72 | HTR6 (0.66) | HTR6ALDH1A1PKMPNMTHTR2C | |
| SCHEMBL3355243 | 0.71 | PNMT (0.63) | HTR6ALDH1A1PKMPNMTHTR2C | |
| SCHEMBL29985647 | 0.71 | GAA (0.65) | HTR6ALDH1A1GAAPKMALOX15 | |
| SCHEMBL6984820 | 0.71 | HTR6 (0.61) | HTR6ALDH1A1GAAPKMIL1RN | |
| Hydrochloric Acid SCHEMBL10563577 | 0.71 | HTR6 (0.82) | HTR6ALDH1A1PNMTHTR2CHTR2B | |
| SCHEMBL3353641 | 0.70 | PNMT (0.52) | HTR6ALDH1A1GAAPNMTHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487801-A1 | 7-ARYLSULFONAMIDO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | claimed |
| WO-2003068751-A1 | 7-ARYLSULFONAMIDO-2,3,4,5-TETRAHYDRO-1H-BENZO'DIAZEPINE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY FOR THE REATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | claimed |