Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.66 |
| ▸ | HTR2C | P28335 | 7/20 | 0.55 |
| ▸ | HTR2B | P41595 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778392 | 0.85 | HTR6 (0.66) | HTR6HTR2CHTR2BALDH1A1PKM | |
| SCHEMBL5778007 | 0.84 | LMNA (0.50) | HTR6HTR2CHTR2BPKMPGR | |
| SCHEMBL6651572 | 0.84 | HTR6 (0.52) | HTR6HTR2CHTR2BALDH1A1PKM | |
| SCHEMBL5781306 | 0.80 | HTR6 (1.00) | HTR6HTR2CHTR2BALDH1A1PKM | |
| SCHEMBL10357482 | 0.75 | HTR6 (0.84) | HTR6HTR2CHTR2BALDH1A1PKM | |
| SCHEMBL7452220 | 0.75 | HTR6 (0.84) | HTR6HTR2CHTR2BALDH1A1PNMT | |
| SCHEMBL29985647 | 0.74 | GAA (0.65) | HTR6ALDH1A1PKMGAAALOX15 | |
| Hydrochloric Acid SCHEMBL10563577 | 0.74 | HTR6 (0.82) | HTR6HTR2CHTR2BALDH1A1PNMT | |
| SCHEMBL1945834 | 0.73 | HTR6 (0.85) | HTR6HTR2CHTR2BALDH1A1PNMT | |
| SCHEMBL5781207 | 0.72 | HTR6 (0.74) | HTR6HTR2CHTR2BPKMPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487801-B1 | 7-ARYLSULFONAMIDO-2,3,4,5-TETRAHYDRO-1H-BENZO¬D|AZEPINE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2006-04-19 | — | — | EP | claimed |
| US-20050090496-A1 | Sulphonyl compounds with 5-ht6 receptor affinity | GLAXO GROUP LIMITED (GB) | 2005-04-28 | — | — | US | claimed |
| US-20050090485-A1 | 7-Arylsulfonamido-2,3,4,5-tetrahydro-1h-benzo'diazepine derivatives with 5ht6 receptor affinity for the reatment of cns disorders | GLAXO GROUP LIMITED (GB) | 2005-04-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090496-A1 | Sulphonyl compounds with 5-ht6 receptor affinity | HTR6, HTR4, HTR5A | HTR6 1/4885HTR2C 8/4885HTR2B 10/4885 |
| US-20050090485-A1 | 7-Arylsulfonamido-2,3,4,5-tetrahydro-1h-benzo'diazepine derivatives with 5ht6 receptor affinity for the reatment of cns disorders | HTR6, HTR7, HTR2A | HTR6 1/4885HTR2C 6/4885HTR2B 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.