Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933112 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6100 | 0.83 | HDAC8 (0.62) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL7124393 | 0.82 | RAB9A (0.55) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL7129356 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL25489176 | 0.81 | HDAC8 (0.61) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| Methane SCHEMBL15893673 | 0.81 | HDAC8 (0.67) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2915137 | 0.81 | HDAC8 (0.60) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL7796539 | 0.81 | HDAC8 (0.60) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5075431 | 0.81 | HDAC8 (0.60) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL11130438 | 0.81 | HDAC8 (0.60) | ALDH1A1KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427419-A1 | IMPROVEMENT OF THE LOCAL COMPATIBILITY DURING INTRAVENOUS ADMINISTRATION OF 4-(4-(2-PYRROLYLCARBONYL)-1-PIPERAZINYL)-3-TRIFLUORMETHYL-BENZOYLGUANIDINE | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-06-16 | — | — | EP | claimed |
| WO-2003022281-A1 | IMPROVEMENT OF THE LOCAL COMPATIBILITY DURING INTRAVENOUS ADMINISTRATION OF 4-(4-(2-PYRROLYLCARBONYL)-1-PIPERAZINYL)-3-TRIFLUORMETHYL-BENZOYLGUANIDINE | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-03-20 | — | — | WO | claimed |
| US-6667356-B2 | Including an n-amidinobenzamide derivative; heat aging resistance | BRIDGESTONE CORPORATION (JP) | 2003-12-23 | — | — | US | disclosed |
| US-20030134947-A1 | Containing imine, amidine or guanidine antioxidants to improve heat aging resistance; may be substituted by acyl, thioacyl or additional imine groups | BRIDGESTONE CORPORATION, OTSUKA CHEMICAL CO., LTD. | 2003-07-17 | — | — | US | disclosed |
| US-6515055-B1 | Excellent in heat aging resistance due to addition of compounds exemplified by N'-(N-benzoylamidino) benzoic acid hydrazide | BRIDGESTONE CORPORATION (JP) | 2003-02-04 | — | — | US | disclosed |
| EP-1101793-A1 | Heat ageing resistant rubber composition | Bridgestone Corporation (JP) | 2001-05-23 | — | — | EP | disclosed |