Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701780 | 0.90 | ALDH1A1 (0.58) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL7129356 | 0.90 | ALDH1A1 (0.54) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL8634915 | 0.87 | ALDH1A1 (0.55) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL6651796 | 0.87 | ALDH1A1 (0.50) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL5674172 | 0.87 | RAB9A (0.57) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL5446555 | 0.87 | ALDH1A1 (0.76) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3070358 | 0.86 | NPC1 (0.67) | ALDH1A1HDAC2HDAC8HDAC6NPC1 | |
| SCHEMBL76489 | 0.85 | ALDH1A1 (0.67) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL3069331 | 0.84 | ALDH1A1 (0.55) | ALDH1A1HDAC3CA12CA1IDO1 | |
| SCHEMBL11400756 | 0.82 | ALDH1A1 (0.46) | ALDH1A1HDAC3CA12CA1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640587-B1 | Diacyl substituted guanidins, process for their preparation, their use as medicament or diagnostic reagent and medicament containing them | HOECHST AG (DE) | 1999-12-29 | — | — | EP | claimed |
| CN-112300459-A | Rubber composition for tire tread and tire produced using the same | 韩国轮胎与科技株式会社 | 2021-02-02 | — | — | CN | disclosed |
| US-20040044081-A1 | Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them | HOECHST AKTIENGESELLSCHAFT | 2004-03-04 | — | — | US | disclosed |
| US-6667356-B2 | Including an n-amidinobenzamide derivative; heat aging resistance | BRIDGESTONE CORPORATION (JP) | 2003-12-23 | — | — | US | disclosed |
| US-6632840-B1 | Inhibiting the Na+/H+ exchanger, treating at least one of arrhythmias and shock | HOECHST AKTIENGESELLSCHAFT (DE) | 2003-10-14 | — | — | US | disclosed |
| US-20030134947-A1 | Containing imine, amidine or guanidine antioxidants to improve heat aging resistance; may be substituted by acyl, thioacyl or additional imine groups | BRIDGESTONE CORPORATION, OTSUKA CHEMICAL CO., LTD. | 2003-07-17 | — | — | US | disclosed |
| US-6515055-B1 | Excellent in heat aging resistance due to addition of compounds exemplified by N'-(N-benzoylamidino) benzoic acid hydrazide | BRIDGESTONE CORPORATION (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6436999-B1 | REACTING GUANIDINE AND CARBOCYCLIC ACIDS, TO FORM COMPOUNDS LIKE BIS(3-METHYLSULFONYL-4-I-PROPYLBENZOYL)GUANIDINE, USED FOR PROPHYLAXIS OF CARDIOVASCULAR DISORDERS AND AS PRODRUGS FOR SODIUM CHANNEL MODULATORS TO CONTROL BLOOD PRESSURE | HOECHST AKTIENGESELLSCHAFT (DE) | 2002-08-20 | — | — | US | disclosed |
| EP-1101793-A1 | Heat ageing resistant rubber composition | Bridgestone Corporation (JP) | 2001-05-23 | — | — | EP | disclosed |
| EP-0640587-B1 | Diacyl substituted guanidins, process for their preparation, their use as medicament or diagnostic reagent and medicament containing them | HOECHST AG (DE) | 1999-12-29 | — | — | EP | disclosed |
| EP-0921117-A2 | Acylguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-06-09 | — | — | EP | disclosed |
| EP-0640587-A1 | Diacyl substituted guanidins, process for their preparation, their use as medicament or diagnostic reagent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044081-A1 | Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them | ADRA1B, ADRA1A, HYOU1 | ALDH1A1 522/4885HDAC3 2392/4885CA12 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.