Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.39 |
| ▸ | MEN1 | O00255 | 10/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220198 | 0.80 | KMT2A (0.51) | YTHDF2KMT2AMEN1LMNAPABPC1 | |
| Hydrochloric Acid SCHEMBL30517206 | 0.79 | KMT2A (0.50) | YTHDF2KMT2AMEN1LMNAPABPC1 | |
| SCHEMBL1263340 | 0.75 | CRBN (0.44) | KMT2AMEN1LMNAMAPTALOX12 | |
| SCHEMBL11049824 | 0.73 | MAPT (0.42) | KMT2AMEN1LMNAMAPTALOX12 | |
| SCHEMBL4435670 | 0.68 | MAPT (0.45) | KMT2AMEN1LMNAMAPTALOX12 | |
| SCHEMBL9008187 | 0.68 | MAPT (0.43) | KMT2AMEN1LMNAMAPTALOX12 | |
| SCHEMBL28286558 | 0.66 | KMT2A (0.42) | YTHDF2KMT2AMEN1LMNAPABPC1 | |
| SCHEMBL8428770 | 0.64 | LMNA (0.36) | KMT2AMEN1LMNAMAPTALOX12 | |
| SCHEMBL11550362 | 0.61 | AHR (0.54) | KMT2AMEN1LMNAMAPTALOX12 | |
| SCHEMBL29094161 | 0.60 | MAPT (0.33) | KMT2AMEN1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |