Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6704731 | 0.84 | CYP1A2 (0.53) | CYP3A4RAB9AALDH1A1CYP1A2CHRM2 | |
| SCHEMBL4331523 | 0.71 | TDP1 (0.70) | CYP3A4CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL6653067 | 0.69 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP2C19DYRK1ALMNA | |
| SCHEMBL6671574 | 0.68 | CYP3A4 (0.49) | CYP3A4CYP2D6CYP2C19DYRK1ALMNA | |
| SCHEMBL6671580 | 0.68 | CYP3A4 (0.56) | CYP3A4CYP2D6CYP2C19LMNAKDM4E | |
| SCHEMBL6634823 | 0.67 | HRH3 (0.66) | CYP3A4CYP2D6CYP2C19DYRK1ALMNA | |
| SCHEMBL11856358 | 0.66 | KDM4E (0.70) | KDM4EGLAPOLBALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11142875 | 0.66 | HRH3 (0.63) | CYP3A4CYP2D6CYP2C19DYRK1ALMNA | |
| SCHEMBL6649246 | 0.66 | CYP3A4 (0.54) | CYP3A4CYP2D6CYP2C19DYRK1ALMNA | |
| SCHEMBL6649751 | 0.66 | CYP2C19 (0.65) | CYP3A4CYP2D6CYP2C19LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |