Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648423 | 0.85 | HRH3 (0.51) | CYP3A4CYP1A2L3MBTL1 | |
| SCHEMBL6650144 | 0.84 | CYP1A2 (0.53) | CYP3A4CYP1A2L3MBTL1 | |
| SCHEMBL11440371 | 0.84 | HTR7 (0.53) | LMNAMAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL13103802 | 0.83 | POLB (0.48) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2375260 | 0.81 | SIGMAR1 (0.46) | CYP3A4CYP2D6CYP2C19LMNACYP1A2 | |
| SCHEMBL23328246 | 0.80 | EPHX2 (0.44) | LMNACYP1A2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24518600 | 0.79 | SIGMAR1 (0.57) | MAPTKDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL19623616 | 0.78 | ALDH1A1 (0.42) | CYP3A4CYP2D6CYP2C19LMNACYP1A2 | |
| SCHEMBL10591990 | 0.78 | CYP2A6 (0.42) | MAPTKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL3229035 | 0.76 | ALDH1A1 (0.44) | LMNAMAPTKDM4EALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |