SCHEMBL6654495

SCHEMBL6654495

Cc1cc(C)c(C)c(C(=O)c2ccc(N)cc2)c1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
MAOA P21397 1/20 0.44
NPC1 O15118 2/20 0.43
POLB P06746 2/20 0.43
MITF O75030 1/20 0.43
MAPT P10636 4/20 0.42
TDP1 Q9NUW8 2/20 0.42
HTT P42858 2/20 0.42
HPGD P15428 2/20 0.42
ALDH1A1 P00352 3/20 0.41
ENPP3 O14638 2/20 0.41
ALPL P05186 2/20 0.41
XIAP P98170 2/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL305564 0.82 LMNA (0.46) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL10439590 0.79 MAPT (0.42) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL31570101 0.76 LMNA (0.71) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL7189766 0.76 NPC1 (0.47) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL31457279 0.76 NPC1 (0.47) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL9097535 0.75 CA12 (0.59) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL204877 0.75 CA12 (0.59) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL62657 0.75 CA12 (0.59) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL7195606 0.74 LMNA (0.54) LMNACYP1A2CYP3A4MAOANPC1
SCHEMBL6323387 0.74 ALDH1A1 (0.76) LMNACYP1A2CYP3A4MAOAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966424-B1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMA AS (DK) 2004-06-23 EP disclosed
US-6313174-B1 FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) 2001-11-06 US disclosed
EP-0966424-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1999-12-29 EP disclosed
WO-1998032730-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-07-30 WO disclosed