Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | ATM | Q13315 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GRM6 | O15303 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2307828 | 0.83 | MAPT (0.60) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL9495325 | 0.81 | LMNA (1.00) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL3599532 | 0.81 | LMNA (0.71) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL3192118 | 0.80 | LMNA (0.69) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL6991094 | 0.80 | CISD2 (0.51) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL2206020 | 0.79 | MCL1 (0.49) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL2688919 | 0.79 | LIMK1 (0.62) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL25904738 | 0.79 | LMNA (0.82) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL1101766 | 0.77 | KDM4E (1.00) | LMNAMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL30173777 | 0.77 | KDM4E (1.00) | LMNAMAPK1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280792-B1 | METHOD FOR PRODUCING BENZO ANNELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2004-07-14 | — | — | EP | claimed |
| US-10329304-B2 | Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase | VANDERBILT UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20170309829-A1 | COMPOSITION FOR ORGANIC OPTOELECTRONIC ELEMENT, ORGANIC OPTOELECTRONIC ELEMENT, AND DISPLAY DEVICE | SAMSUNG SDI CO., LTD. (KR) | 2017-10-26 | — | — | US | disclosed |
| US-20170309829-A1 | COMPOSITION FOR ORGANIC OPTOELECTRONIC ELEMENT, ORGANIC OPTOELECTRONIC ELEMENT, AND DISPLAY DEVICE | SAMSUNG SDI CO., LTD. (KR) | 2017-10-26 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170012216-A1 | CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME | SAMSUNG SDI CO., LTD. (KR) | 2017-01-12 | — | — | US | disclosed |
| US-20170012216-A1 | CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME | SAMSUNG SDI CO., LTD. (KR) | 2017-01-12 | — | — | US | disclosed |
| US-20160240791-A1 | COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE | SAMSUNG SDI CO., LTD. (KR) | 2016-08-18 | — | — | US | disclosed |
| US-20160240791-A1 | COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE | SAMSUNG SDI CO., LTD. (KR) | 2016-08-18 | — | — | US | disclosed |
| US-6723848-B2 | TETRAHYDROBENZOFURAN OR TETRAHYDROBENZOTHIOPHEN OR TETRAHDYROBENZOPYRROLE COMPOUNDS CAN BE AROMATIZED WITH A HYDROGENATION CATALYST IN PRESENCE OF A HYDROGEN ACCEPTOR, DEACYLATION OF AMINO GROUP BY ADDITION OF AN AMINE GROUP | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2004-04-20 | — | — | US | disclosed |
| US-6689885-B2 | REACTING AMINOBENZOTHIOPHENE-3-CARBOXYLIC ESTER COMPOUND WITH NITRILE COMPOUND IN SOLUTION OR SUSPENSION IN A SOLVENT IN THE PRESENCE OF AN ACID TO OBTAIN THIENOPYRIMIDINE COMPOUND | MERCK PATENT GMBH (DE) | 2004-02-10 | — | — | US | disclosed |
| US-20030096994-A1 | Method for producing thienopyrimidines | MERCK PATENT GMBH (DE) | 2003-05-22 | — | — | US | disclosed |
| US-20030078422-A1 | Method for producing benzo annelated heterocycles | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329304-B2 | Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase | PDE4A, PDE4B, PDE7A | LMNA 3846/4885MAPK1 916/4885MEN1 1826/4885 |
| US-20030096994-A1 | Method for producing thienopyrimidines | NUDT1, TYMP, TPMT | LMNA 3289/4885MAPK1 1660/4885MEN1 1470/4885 |
| US-20170309829-A1 | COMPOSITION FOR ORGANIC OPTOELECTRONIC ELEMENT, ORGANIC OPTOELECTRONIC ELEMENT, AND DISPLAY DEVICE | OCIAD2, OCIAD1, OR10J3 | LMNA 4816/4885MAPK1 455/4885MEN1 2593/4885 |
| US-20170012216-A1 | CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME | CRY1, CRY2, CCNE2 | LMNA 1491/4885MAPK1 3987/4885MEN1 838/4885 |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | LMNA 3846/4885MAPK1 916/4885MEN1 1826/4885 |
| US-20160240791-A1 | COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE | OR10J3, OXER1, OCIAD1 | LMNA 4847/4885MAPK1 473/4885MEN1 3118/4885 |
| US-20030078422-A1 | Method for producing benzo annelated heterocycles | NAT1, AFF1, SAT1 | LMNA 3472/4885MAPK1 1004/4885MEN1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.