Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228969 | 0.98 | HPGD (0.56) | HPGDMAPTXBP1NPSR1KMT2A | |
| SCHEMBL2149614 | 0.85 | MAPT (0.71) | HPGDMAPTXBP1NPSR1KMT2A | |
| SCHEMBL125031 | 0.85 | HPGD (0.56) | HPGDMAPTXBP1NPSR1KMT2A | |
| SCHEMBL5689370 | 0.84 | CTNNB1 (0.57) | HPGDMAPTNPSR1KMT2AMEN1 | |
| Bicarbonate SCHEMBL7114860 | 0.84 | ESR1 (0.50) | MAPTNPSR1KMT2AESR1ESR2 | |
| SCHEMBL7123691 | 0.83 | KMT2A (0.45) | HPGDMAPTXBP1NPSR1KMT2A | |
| SCHEMBL4343858 | 0.82 | ESR1 (0.51) | MAPTNPSR1KMT2AESR1ESR2 | |
| SCHEMBL4334988 | 0.82 | MAPT (0.46) | HPGDMAPTXBP1NPSR1KMT2A | |
| SCHEMBL4342985 | 0.82 | IRAK4 (0.54) | HPGDMAPTXBP1NPSR1KMT2A | |
| SCHEMBL446339 | 0.81 | HPGD (0.59) | HPGDMAPTXBP1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427770-A1 | PROCESS FOR THE PRODUCTION OF POLYCARBONATE | GENERAL ELECTRIC COMPANY (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022905-A1 | PROCESS FOR THE PRODUCTION OF POLYCARBONATE | GENERAL ELECTRIC COMPANY (US) | 2003-03-20 | — | — | WO | disclosed |