SCHEMBL2228969

SCHEMBL2228969

COc1ccccc1C(=O)OC(=O)Oc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.56
MAPT P10636 2/20 0.56
XBP1 P17861 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
KMT2A Q03164 4/20 0.51
ESR1 P03372 2/20 0.49
ESR2 Q92731 1/20 0.49
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 2/20 0.48
SLC6A3 Q01959 1/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 1/20 0.46
HSD17B10 Q99714 3/20 0.46
KDM4E B2RXH2 1/20 0.46
CTSD P07339 1/20 0.46
HTT P42858 1/20 0.46
TSHR P16473 1/20 0.46
POLB P06746 1/20 0.45
ALOX15 P16050 1/20 0.45
CYP1A2 P05177 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL6654633 0.98 HPGD (0.55) HPGDMAPTXBP1NPSR1KMT2A
SCHEMBL2149614 0.86 MAPT (0.71) HPGDMAPTXBP1NPSR1KMT2A
SCHEMBL125031 0.86 HPGD (0.56) HPGDMAPTXBP1NPSR1KMT2A
SCHEMBL5689370 0.85 CTNNB1 (0.57) HPGDMAPTNPSR1KMT2AMEN1
SCHEMBL7123691 0.84 KMT2A (0.45) HPGDMAPTXBP1NPSR1KMT2A
SCHEMBL4343858 0.83 ESR1 (0.51) MAPTNPSR1KMT2AESR1ESR2
SCHEMBL4342985 0.83 IRAK4 (0.54) HPGDMAPTXBP1NPSR1KMT2A
SCHEMBL4334988 0.83 MAPT (0.46) HPGDMAPTXBP1NPSR1KMT2A
SCHEMBL446339 0.82 HPGD (0.59) HPGDMAPTXBP1NPSR1KMT2A
Bicarbonate SCHEMBL7114860 0.82 ESR1 (0.50) MAPTNPSR1KMT2AESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567577-B1 METHOD FOR MAKING STABLE, HOMOGENEOUS MELT SOLUTIONS GEN ELECTRIC (US) 2008-05-21 EP claimed
EP-1567577-A1 METHOD FOR MAKING STABLE, HOMOGENEOUS MELT SOLUTIONS GENERAL ELECTRIC COMPANY (US) 2005-08-31 EP claimed
US-6900283-B2 Method for making stable, homogeneous melt solutions GENERAL ELECTRIC COMPANY (US) 2005-05-31 US claimed
WO-2004041908-A1 METHOD FOR MAKING STABLE, HOMOGENEOUS MELT SOLUTIONS GENERAL ELECTRIC COMPANY (US) 2004-05-21 WO claimed
US-20040087756-A1 METHOD FOR MAKING STABLE, HOMOGENEOUS MELT SOLUTIONS GENERAL ELECTRIC COMPANY 2004-05-06 US claimed
EP-3247734-B1 PREPARATION OF HIGHLY HEAT-RESISTANT (EO)POIYCARBONATES BY THE TRANSESTERIFICATION METHOD COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2022-08-31 EP disclosed
EP-2365957-B1 METHOD FOR MAKING CARBONATES AND ESTERS SABIC GLOBAL TECHNOLOGIES BV (NL) 2020-04-22 EP disclosed
US-10370491-B2 Preparation of highly heat-resistant (co)polycarbonates by the transesterification method COVESTRO DEUTSCHLAND AG (DE) 2019-08-06 US disclosed
US-20170369642-A1 Preparation of Highly Heat-Resistant (Co)Polycarbonates by the Transesterification Method COVESTRO DEUTSCHLAND AG (DE) 2017-12-28 US disclosed
EP-3247734-A1 PREPARATION OF HIGHLY HEAT-RESISTANT (EO)POIYCARBONATES BY THE TRANSESTERIFICATION METHOD Covestro Deutschland AG (DE) 2017-11-29 EP disclosed
WO-2016116480-A1 PREPARATION OF HIGHLY HEAT-RESISTANT (EO)POIYCARBONATES BY THE TRANSESTERIFICATION METHOD COVESTRO DEUTSCHLAND AG (DE) 2016-07-28 WO disclosed
EP-2300414-B1 METHOD FOR PRODUCING PHENOLIC COMPOUND SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-04-27 EP disclosed
EP-1348003-A1 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2003-10-01 EP disclosed
US-20030120025-A1 Process for the production of polycarbonate GENERAL ELECTRIC COMPANY 2003-06-26 US disclosed
WO-2003031497-A1 METHOD FOR END-CAPPING POLYCARBONATE RESINS AND COMPOSITION FOR USE IN SAME GENERAL ELECTRIC COMPANY (US) 2003-04-17 WO disclosed
WO-2003022905-A1 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2003-03-20 WO disclosed
US-6525163-B1 Reducing static charge, improving heat aging, and lowering water absorption by increasing endcap levels GENERAL ELECTRIC COMPANY 2003-02-25 US disclosed
US-6500914-B1 MELT TRANSESTERIFICATION OF FREE HYDROXYL TERMINAL GROUPS WITH A DIARYL CARBONATE GENERAL ELECTRIC COMPANY 2002-12-31 US disclosed
US-20020128425-A1 Process for the production of polycarbonate GENERAL ELECTRIC COMPANY 2002-09-12 US disclosed
WO-2002060977-A1 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2002-08-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030120025-A1 Process for the production of polycarbonate RNGTT, CAPG, RPL30 HPGD 4508/4885MAPT 3934/4885XBP1 1563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.