Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.54 |
| ▸ | MMP13 | P45452 | 10/20 | 0.52 |
| ▸ | MMP1 | P03956 | 6/20 | 0.52 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656854 | 0.88 | ADAM17 (0.54) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6656569 | 0.88 | ADAM17 (0.54) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7522928 | 0.87 | ADAM17 (0.50) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6787090 | 0.85 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6786688 | 0.82 | ADAM17 (0.62) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6785940 | 0.80 | ADAM17 (0.56) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7325352 | 0.74 | ADAM17 (0.79) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7313621 | 0.72 | ADAM17 (0.56) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6506632 | 0.72 | MMP13 (0.80) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL995167 | 0.71 | ADAM17 (0.53) | ADAM17MMP13MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |