Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.50 |
| ▸ | MMP13 | P45452 | 12/20 | 0.48 |
| ▸ | MMP1 | P03956 | 5/20 | 0.48 |
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654897 | 0.87 | ADAM17 (0.54) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6785940 | 0.80 | ADAM17 (0.56) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6656569 | 0.75 | ADAM17 (0.54) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6656854 | 0.75 | ADAM17 (0.54) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6787090 | 0.73 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7325352 | 0.71 | ADAM17 (0.79) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6786688 | 0.70 | ADAM17 (0.62) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7313621 | 0.69 | ADAM17 (0.56) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6654890 | 0.69 | MMP13 (0.58) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL6506632 | 0.69 | MMP13 (0.80) | ADAM17MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |