SCHEMBL6655754

SCHEMBL6655754

COCOc1ccc(C(=O)C(F)(F)F)cc1

nearest known ligand 0.49

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 14/20 0.49
CES1 P23141 1/20 0.46
MAPT P10636 1/20 0.43
FYN P06241 1/20 0.42
MAOB P27338 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13624173 0.85 MLYCD (0.55) MLYCDCES1MAPTL3MBTL1
SCHEMBL17853880 0.83 MAPT (0.43) MAPTFYNL3MBTL1
SCHEMBL8444552 0.82 PARP10 (0.59) MLYCDMAPTMAOB
SCHEMBL25846701 0.81 MLYCD (0.57) MLYCDCES1MAOBL3MBTL1
SCHEMBL29645006 0.80 MLYCD (0.56) MLYCDMAPTL3MBTL1
SCHEMBL9549256 0.80 KMT2A (0.53) MAPTFYNL3MBTL1
SCHEMBL1398393 0.80 CES1 (0.59) MLYCDCES1MAPT
SCHEMBL3798190 0.80 CES2 (0.59) CES1MAPTFYNL3MBTL1
SCHEMBL15000339 0.79 TP53 (0.58) MLYCDL3MBTL1
SCHEMBL686115 0.79 FYN (0.36) MAPTFYNMAOBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040254241-A1 Enzyme inhibitor; cognition activators KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-12-16 US disclosed
EP-1431280-A1 ARYL SULFAMATE DERIVATIVES Kyowa Hakko Kogyo Co., Ltd (JP) 2004-06-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040254241-A1 Enzyme inhibitor; cognition activators SULT1A1, STS, CYP26A1 MLYCD 4438/4885CES1 4/4885MAPT 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.