Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 3/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655803 | 1.00 | MKNK1 (0.49) | MKNK1MKNK2CCNB2CDK1CDK4 | |
| SCHEMBL6753899 | 0.83 | CYP2A6 (0.52) | MKNK1MKNK2ALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL6753897 | 0.83 | CYP2A6 (0.52) | MKNK1MKNK2ALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL29569162 | 0.83 | ERN1 (0.57) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL958907 | 0.83 | ERN1 (0.57) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL457158 | 0.81 | CYP11B1 (0.61) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL457159 | 0.81 | CYP11B1 (0.61) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL29881470 | 0.81 | CYP11B1 (0.61) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL4822624 | 0.80 | CYP2A6 (0.52) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL408645 | 0.79 | ALDH1A1 (0.65) | CCNB2CDK1CDK4CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1589277-A | 6-O-carbamate-11,12-lacto-ketolide antimicrobials | ORTHO MCNEIL PHARM INC (US) | 2005-03-02 | — | — | CN | disclosed |
| EP-1430068-A1 | 6-O-CARBAMATE-11,12-LACTO-KETOLIDE ANTIMICROBIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| US-6713455-B2 | A BICYCLIC HETEROAROMATIC COMPOUND CONTAINING TWO KETO, TWO ESTER, A CARBAMATE GROUPS AND A METHYL, HYDROXY AND AMINE SUBSTITUTED OXYPYRAN RING; USEFUL ANTIBACTERIAL AGENT FOR TREATING PNEUMONIA, SKIN, SOFT TISSUE AND BONE INFECTIONS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-03-30 | — | — | US | disclosed |
| US-20030125267-A1 | 6-O-carbamate-11,12-lacto-ketolide antimicrobials | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-07-03 | — | — | US | disclosed |
| WO-2003024986-A1 | 6-O-CARBAMATE-11,12-LACTO-KETOLIDE ANTIMICROBIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125267-A1 | 6-O-carbamate-11,12-lacto-ketolide antimicrobials | ARG1, LPO, Q6ZSR9 | MKNK1 2922/4885MKNK2 3878/4885CCNB2 2555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.