Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417021 | 0.94 | PIM1 (0.42) | PIM1KDM4EADRB2GAAL3MBTL1 | |
| SCHEMBL20061124 | 0.94 | PIM1 (0.42) | PIM1KDM4EADRB2GAAL3MBTL1 | |
| SCHEMBL13303583 | 0.94 | PIM1 (0.42) | PIM1KDM4EADRB2GAAL3MBTL1 | |
| SCHEMBL22647693 | 0.91 | PIM1 (0.41) | PIM1KDM4EADRB2GAAL3MBTL1 | |
| SCHEMBL9885359 | 0.83 | PIM1 (0.38) | PIM1KDM4EADRB2 | |
| SCHEMBL104650 | 0.78 | TAS1R3 (0.44) | PIM1KDM4ETAS1R3TAS1R1 | |
| SCHEMBL10130312 | 0.78 | TAS1R3 (0.44) | PIM1KDM4ETAS1R3TAS1R1 | |
| SCHEMBL25589731 | 0.78 | TAS1R3 (0.44) | PIM1KDM4ETAS1R3TAS1R1 | |
| SCHEMBL24316216 | 0.78 | ALDH1A1 (0.48) | PIM1KDM4EGAAL3MBTL1 | |
| SCHEMBL20063364 | 0.78 | KDM4E (0.38) | PIM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160267-B1 | CATALYST FOR OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, METHOD OF OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, AND POLY(OXYFLUOROPHENYLENE) DERIVATIVE | JAPAN SCIENCE & TECH CORP (JP) | 2004-08-04 | — | — | EP | disclosed |