Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13112151 | 0.85 | CYP11B1 (0.48) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL18573186 | 0.83 | CYP11B1 (0.46) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL18573204 | 0.83 | CYP11B1 (0.46) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL10160338 | 0.81 | POLB (0.48) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL18573398 | 0.80 | CYP11B1 (0.46) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL9000479 | 0.80 | LDHA (0.43) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL6655528 | 0.79 | ALDH1A1 (0.52) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL6655522 | 0.79 | ALDH1A1 (0.52) | LDHACYP11B1CYP11B2HPGDSCYP3A4 | |
| SCHEMBL5293356 | 0.77 | ALDH1A1 (0.62) | LDHAHPGDSBAZ2BKDM4EMITF | |
| SCHEMBL5293348 | 0.77 | ALDH1A1 (0.62) | LDHAHPGDSBAZ2BKDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1589277-A | 6-O-carbamate-11,12-lacto-ketolide antimicrobials | ORTHO MCNEIL PHARM INC (US) | 2005-03-02 | — | — | CN | disclosed |
| EP-1430068-A1 | 6-O-CARBAMATE-11,12-LACTO-KETOLIDE ANTIMICROBIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| US-6713455-B2 | A BICYCLIC HETEROAROMATIC COMPOUND CONTAINING TWO KETO, TWO ESTER, A CARBAMATE GROUPS AND A METHYL, HYDROXY AND AMINE SUBSTITUTED OXYPYRAN RING; USEFUL ANTIBACTERIAL AGENT FOR TREATING PNEUMONIA, SKIN, SOFT TISSUE AND BONE INFECTIONS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-03-30 | — | — | US | disclosed |
| US-20030125267-A1 | 6-O-carbamate-11,12-lacto-ketolide antimicrobials | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-07-03 | — | — | US | disclosed |
| WO-2003024986-A1 | 6-O-CARBAMATE-11,12-LACTO-KETOLIDE ANTIMICROBIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125267-A1 | 6-O-carbamate-11,12-lacto-ketolide antimicrobials | ARG1, LPO, Q6ZSR9 | LDHA 42/4885CYP11B1 2812/4885CYP11B2 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.