Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.38 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7195481 | 0.80 | CA2 (0.57) | ACLYTDP1MEN1KMT2ACDK2 | |
| SCHEMBL7186444 | 0.78 | CA2 (0.45) | ACLYTDP1MEN1KMT2ACDK2 | |
| SCHEMBL32664392 | 0.78 | CYP1A2 (0.51) | ACLYTDP1MEN1KMT2ACDK2 | |
| SCHEMBL5806023 | 0.76 | ALDH1A1 (0.55) | POLBALDH1A1HSD17B10L3MBTL1GAA | |
| SCHEMBL1111419 | 0.75 | NSD2 (0.50) | ACLYTDP1MEN1KMT2AKDM4E | |
| SCHEMBL8942179 | 0.75 | IL1RN (0.55) | ACLYTDP1MEN1KMT2APTPN1 | |
| SCHEMBL30013888 | 0.75 | TDP1 (0.44) | ACLYTDP1MEN1KMT2ACDK2 | |
| SCHEMBL1491236 | 0.75 | TDP1 (0.44) | ACLYTDP1MEN1KMT2ACDK2 | |
| SCHEMBL5805374 | 0.74 | GAA (0.58) | TDP1MEN1KMT2ACA2CA12 | |
| SCHEMBL15973217 | 0.74 | KAT6A (0.50) | TDP1MEN1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438298-A1 | PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY | Pfizer Products Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003035627-A1 | PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY | PFIZER PRODUCTS INC. (US) | 2003-05-01 | — | — | WO | disclosed |