Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.68 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19231706 | 0.91 | TDP1 (0.62) | LTA4HSLC2A1RAB9ANPC1MAPK1 | |
| SCHEMBL19080586 | 0.84 | HTR1A (0.63) | SLC2A1RAB9ANPC1MAPK1HRH3 | |
| SCHEMBL6658840 | 0.84 | RAB9A (0.86) | LTA4HRAB9ANPC1MAPK1HRH3 | |
| SCHEMBL1899201 | 0.82 | LTA4H (1.00) | LTA4HRAB9ANPC1HRH3KCNH2 | |
| SCHEMBL14970484 | 0.80 | LTA4H (0.97) | LTA4HRAB9ANPC1HRH3KCNH2 | |
| SCHEMBL4237405 | 0.79 | LTA4H (0.72) | LTA4HRAB9ANPC1MAPK1HRH3 | |
| SCHEMBL13150048 | 0.78 | TDP1 (0.65) | LTA4HMAPK1HRH3TDP1 | |
| SCHEMBL13103634 | 0.78 | HRH3 (0.64) | LTA4HRAB9ANPC1HRH3 | |
| SCHEMBL11898739 | 0.78 | NPC1 (0.97) | LTA4HRAB9ANPC1HRH3KCNH2 | |
| SCHEMBL1776344 | 0.75 | MEN1 (0.55) | SLC2A1RAB9ANPC1MAPK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463731-A1 | DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE | Abbott GmbH & Co. KG (DE) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003057699-A1 | DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |