Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CHAT | P28329 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381110 | 0.91 | SMN1; SMN2 (0.47) | HDAC8ACHETSHRHRH1PDE4D | |
| SCHEMBL11773830 | 0.86 | HDAC8 (0.66) | HDAC8ACHETSHRHRH1PDE4D | |
| SCHEMBL1426032 | 0.82 | — | — | |
| SCHEMBL5200858 | 0.82 | HDAC8 (0.46) | HDAC8ACHETSHRHRH1PDE4D | |
| Formic Acid SCHEMBL29187866 | 0.81 | HDAC8 (0.55) | HDAC8ACHETSHRHRH1PDE4D | |
| Hydrochloric Acid SCHEMBL1601042 | 0.80 | HDAC8 (0.59) | HDAC8ACHETSHRHRH1PDE4D | |
| SCHEMBL9142531 | 0.77 | HDAC8 (0.62) | HDAC8ACHETSHRHRH1PDE4D | |
| SCHEMBL15823402 | 0.77 | ALDH1A1 (0.45) | TSHRKDM4ESMN1; SMN2RAB9ALMNA | |
| SCHEMBL11386719 | 0.77 | RAB9A (0.51) | HDAC8KDM4ESMN1; SMN2RAB9ALMNA | |
| SCHEMBL11386724 | 0.77 | RAB9A (0.51) | HDAC8KDM4ESMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434560-A1 | METHOD FOR DYEING AND SUBSEQUENT BLEACHING OF HAIR | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003030849-A1 | METHOD FOR DYEING AND SUBSEQUENT BLEACHING OF HAIR | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | disclosed |