Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692486 | 0.85 | L3MBTL1 (0.49) | KMT2AMEN1LMNAALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL6662221 | 0.75 | HRH3 (0.62) | KMT2AMEN1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL2636547 | 0.71 | MEN1 (0.68) | FAAHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL4576736 | 0.70 | L3MBTL1 (0.69) | FAAHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL3026559 | 0.70 | CYP2C9 (0.67) | FAAHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL8904897 | 0.69 | ALDH1A1 (0.64) | FAAHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL6658354 | 0.69 | HRH3 (0.58) | FAAHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL7419173 | 0.69 | CYP2C9 (0.65) | FAAHKMT2AMEN1LMNACYP2C9 | |
| SCHEMBL14252818 | 0.69 | MEN1 (0.64) | FAAHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL12466880 | 0.69 | MEN1 (0.64) | FAAHKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441728-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | Vertex Pharmaceuticals Incorporated (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037338-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-1257544-A2 | PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE | Vertex Pharmaceuticals Incorporated (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001058891-A2 | PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-08-16 | — | — | WO | disclosed |