Sugi Predict

Sugi Predict / Compounds / SCHEMBL4576736

SCHEMBL4576736

SCHEMBL4576736

O=C(O)C(=O)N1CCC(Cc2ccccc2)CC1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.69
▸ MEN1 O00255 1/20 0.66
▸ KMT2A Q03164 1/20 0.66
▸ FAAH O00519 1/20 0.66
▸ GRIN2D O15399 1/20 0.64
▸ GRIN3B O60391 1/20 0.64
▸ GRIN1 Q05586 1/20 0.64
▸ GRIN2A Q12879 1/20 0.64
▸ GRIN2B Q13224 1/20 0.64
▸ GRIN2C Q14957 1/20 0.64
▸ GRIN3A Q8TCU5 1/20 0.64
▸ MGLL Q99685 1/20 0.64
▸ TACR3 P29371 1/20 0.63
▸ CYP2C9 P11712 3/20 0.62
▸ CYP2C19 P33261 3/20 0.62
▸ MAPK14 Q16539 3/20 0.62
▸ HTR2B P41595 2/20 0.62
▸ LMNA P02545 1/20 0.62
▸ GAA P10253 1/20 0.62
▸ KCNH2 Q12809 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4576675 0.89 L3MBTL1 (0.64) L3MBTL1MEN1KMT2AFAAHGRIN2D
SCHEMBL13589533 0.89 L3MBTL1 (0.68) L3MBTL1MEN1KMT2AFAAHGRIN2D
SCHEMBL2636547 0.88 MEN1 (0.68) L3MBTL1MEN1KMT2AFAAHMGLL
SCHEMBL3026559 0.86 CYP2C9 (0.67) L3MBTL1MEN1KMT2AFAAHMGLL
SCHEMBL136106 0.85 MEN1 (0.59) L3MBTL1MEN1KMT2AGRIN2DGRIN3B
SCHEMBL4578422 0.85 ALDH1A1 (0.57) L3MBTL1MEN1KMT2AFAAHGRIN2D
SCHEMBL4576966 0.85 FAAH (0.61) L3MBTL1FAAHGRIN2DGRIN3BGRIN1
SCHEMBL7419173 0.85 CYP2C9 (0.65) MEN1KMT2AFAAHMGLLTACR3
SCHEMBL14252818 0.85 MEN1 (0.64) L3MBTL1MEN1KMT2AFAAHMGLL
SCHEMBL12466880 0.85 MEN1 (0.64) L3MBTL1MEN1KMT2AFAAHMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7435744-B2 Piperidine derivatives as NMDA receptor antagonists GEDEON RICHTER VEGYESZETI GYAR RT (HU) 2008-10-14 — — US disclosed
EP-1409477-B1 PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS RICHTER GEDEON NYRT (HU) 2008-09-17 — — EP disclosed
CN-100413860-C piperidine derivatives as NMDA receptor antagonists HUNGARY GIREL GYOGYSZERGYAR (HU) 2008-08-27 — — CN disclosed
US-7378431-B2 Amide derivatives as NMDA receptor antagonists RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2008-05-27 — — US disclosed
US-7375116-B2 Amide derivatives as NMDA receptor antagonists RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2008-05-20 — — US disclosed
US-7365083-B2 Amide derivatives as NMDA receptor antagonists RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2008-04-29 — — US disclosed
US-7361670-B2 Amide derivatives as NMDA receptor antagonists RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2008-04-22 — — US disclosed
US-20050159451-A1 Amide derivatives as NMDA receptor antagonists HORVATH CSILLA (HU) 2005-07-21 — — US disclosed
US-6919355-B2 Amide derivatives as NMDA receptor antagonists RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2005-07-19 — — US disclosed
US-20050113359-A1 Amide derivatives as NMDA receptor antagonists HORVATH CSILLA (HU) 2005-05-26 — — US disclosed
US-20050113361-A1 Amide derivatives as NMDA receptor antagonists HORVATH CSILLA (HU) 2005-05-26 — — US disclosed
US-20050113360-A1 Amide derivatives as NMDA receptor antagonists HORVATH CSILLA (HU) 2005-05-26 — — US disclosed
CN-1556805-A piperidine derivatives as NMDA receptor antagonists ������ҩ�����޹�˾ 2004-12-22 — — CN disclosed
US-20040157886-A1 Piperdine derivatives as NMDA receptor antagonists UCB Biopharma SRL (BE) 2004-08-12 — — US disclosed
EP-1409477-A1 PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) 2004-04-21 — — EP disclosed
US-20030199552-A1 Amide derivatives as NMDA receptor antagonists RICHTER GEDEON VEGYESZETI GYAR RT. 2003-10-23 — — US disclosed
WO-2003010159-A1 PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS Richter Gedeon Vegyészeti Gyár Rt. (HU) 2003-02-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113361-A1 Amide derivatives as NMDA receptor antagonists GRIN1, GRIN3A, GRIN2B L3MBTL1 3064/4885MEN1 2735/4885KMT2A 525/4885
US-20050113360-A1 Amide derivatives as NMDA receptor antagonists GRIN1, GRIN3A, GRIN2B L3MBTL1 3238/4885MEN1 3002/4885KMT2A 548/4885
US-20040157886-A1 Piperdine derivatives as NMDA receptor antagonists GRIN1, GRIN2D, GRIN2C L3MBTL1 4145/4885MEN1 2584/4885KMT2A 1234/4885
US-20050159451-A1 Amide derivatives as NMDA receptor antagonists GRIN1, GRIN3A, GRIN2B L3MBTL1 3254/4885MEN1 2664/4885KMT2A 514/4885
US-20050113359-A1 Amide derivatives as NMDA receptor antagonists GRIN1, GRIN3A, GRIN2B L3MBTL1 3006/4885MEN1 2684/4885KMT2A 503/4885
US-20030199552-A1 Amide derivatives as NMDA receptor antagonists GRIN1, GRIN3A, GRIN2C L3MBTL1 2786/4885MEN1 4425/4885KMT2A 760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.