Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 17/20 | 0.53 |
| ▸ | MMP13 | P45452 | 10/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.53 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656469 | 0.77 | ADAM17 (0.56) | ADAM17MMP13MMP9MMP8MMP1 | |
| SCHEMBL6655286 | 0.75 | ADAM17 (0.51) | ADAM17MMP13MMP9MMP2MMP1 | |
| SCHEMBL6656959 | 0.74 | ADAM17 (0.52) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6656714 | 0.74 | ADAM17 (0.45) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL6662479 | 0.73 | ADAM17 (0.44) | ADAM17MMP13MMP9POLB | |
| SCHEMBL6658737 | 0.72 | ADAM17 (0.78) | ADAM17MMP13MMP9MMP2MMP1 | |
| SCHEMBL6656661 | 0.70 | ADAM17 (0.44) | ADAM17MMP13MMP9POLBMMP1 | |
| SCHEMBL6654871 | 0.70 | ADAM17 (0.43) | ADAM17MMP13MMP9MMP2MMP1 | |
| SCHEMBL3937230 | 0.70 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6660841 | 0.70 | MAOB (0.43) | ADAM17MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |