SCHEMBL6660765

SCHEMBL6660765

CCCc1ccc(C(F)(F)OC(C)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
TAAR1 Q96RJ0 1/20 0.41
KCNH2 Q12809 3/20 0.41
TMEM97 Q5BJF2 3/20 0.41
ALDH1A1 P00352 1/20 0.40
PSMB5 P28074 1/20 0.39
PDE2A O00408 1/20 0.39
MAOB P27338 1/20 0.37
IDO1 P14902 1/20 0.37
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
TSHR P16473 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6661128 0.95 KMT2A (0.36) MEN1KMT2ATAAR1KCNH2TMEM97
SCHEMBL6666034 0.91 TSHR (0.34) MEN1KMT2ATAAR1KCNH2TMEM97
SCHEMBL6661858 0.90 HTR2A (0.40) MEN1KMT2ATAAR1KCNH2TMEM97
SCHEMBL6661144 0.90 KMT2A (0.43) MEN1KMT2ATAAR1ALDH1A1PSMB5
SCHEMBL6661968 0.89 HTR2A (0.40) ALDH1A1CYP3A4
SCHEMBL6662750 0.89 HTR2A (0.40) ALDH1A1CYP3A4
SCHEMBL6662033 0.88 ALDH1A1 (0.42) MEN1KMT2ATAAR1KCNH2TMEM97
SCHEMBL6666707 0.86 PDE2A (0.42) MEN1KMT2AALDH1A1PSMB5PDE2A
SCHEMBL6662955 0.85 HTR2A (0.42) ALDH1A1CYP3A4
SCHEMBL6663310 0.85 DAO (0.37) MEN1KMT2APSMB5PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893423-B1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED LINKAGES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORP (JP) 2004-09-01 EP disclosed